CELLULAR
ASSAYS
Signal Transduction
The epidermal growth
factor receptor (EGFR)
is a member of the type 1 receptor tyrosine kinase (RTK) family and a key regulator of development and growth in cells.
Protein kinase C (PKC)
has an important physiological role in several indications ranging from diabetic neuropathy to transplant rejection, inflammation, neurodegeneration and cancer.
G-protein coupled
receptors (GPCRs)
constitute the largest class of drug targets currently under therapeutic investigation.
Chemokine receptors
play a fundamental role in lymphocyte trafficking. They interact with chemokines produced at sites of infection or destruction and specific areas of lymphoid tissue, and direct the migration of lymphocytes towards these sites.
Virus Infection
Traditional cell-based assays for monitoring viral infection utilize either a cytopathic effect (CPE) assay, a plaque assay, a PCR amplification of viral genetic materials, a gene reporter assay, or a combination of the above.
Ion Channels
Ion channels comprise one of the most important classes of drug targets currently under therapeutic investigation.
COMPOUND
AGGREGATION
Small molecule compound aggregation is a major problem encountered in primary screening assays. Once formed, the aggregates can sequester, cause partial unfolding, inhibit or inactivate a protein.
GENERAL
TECHNICAL
NOTES
Corning® Epic® Cell-based Assays: Tolerance to DMSO Mismatching in Antagonist Assays
Impact of Cell Plating Medium on Corning® Epic® Cell-Based Assay Performance
Data Analysis for G Protein-Coupled Receptor Assays Using Corning® Epic® Technology
Corning® Epic® Label-Free Cell Based Assay: Development of a One-Day Assay for Adherent Cells